to produce the multicomponent vaccine against diarrhea, a translational fusion with the cholera toxin b subunit ( ctb ) upstream of cs3, which is one of the prevalent colonization factors ( cfs ) found in human etec strains, was constructed 為研制有效的廣譜亞單位疫苗,將霍亂毒素b亞單位(ctb)和etec的優(yōu)勢抗原之一cs3分別作為抗毒素免疫和抗黏附免疫的免疫抗原。